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TheraPepNet

Therapeutic Peptide Information

Anti-angiogenic Peptide

Anti-angiogenic peptides are short peptides capable of inhibiting new blood vessel formation. They exert their effects by interfering with the proliferation, migration, and lumen formation of endothelial cells, and are commonly used in the treatment of cancer and other diseases associated with abnormal angiogenesis. Due to their specificity and lower side effects, anti-angiogenic peptides have garnered significant attention in drug development, with research indicating that these peptides can effectively reduce tumor growth and the risk of metastasis.

Anti-bacterial Peptide

Anti-bacterial peptides are naturally occurring short peptides that effectively combat bacterial infections. They exert their antibacterial effects by disrupting bacterial cell membranes, interfering with bacterial metabolism, and modulating immune responses. Due to their broad-spectrum activity and low likelihood of resistance, antibacterial peptides show great promise in infection treatment, particularly as powerful alternatives to traditional antibiotics in the fight against resistant bacteria. Research also suggests that antibacterial peptides may have wide-ranging applications in skincare and food preservation.

Anti-cancer Peptide

Anti-cancer peptides are short peptides that can inhibit tumor growth and metastasis. They work through various mechanisms, including inducing apoptosis in cancer cells, suppressing cell proliferation, blocking angiogenesis, and enhancing immune responses. Due to their high specificity and lower side effects, anticancer peptides have garnered significant attention in cancer therapy and are considered potential targeted treatment agents. Research has shown that these peptides exhibit strong antitumor activity across different types of cancer and hold promise for use in combination with other therapies to enhance efficacy.

Anti-inflammatory Peptide

Anti-inflammatory peptides are short peptides that can reduce inflammatory responses. They work by inhibiting the release of inflammatory mediators, modulating the activity of immune cells, and promoting tissue repair. Due to their specificity and minimal side effects, anti-inflammatory peptides show great promise in treating various inflammation-related diseases, such as autoimmune disorders, arthritis, and cardiovascular diseases. Research indicates that these peptides not only effectively alleviate inflammation symptoms but also contribute to overall health improvement.

Anti-viral Peptide

Anti-viral peptides are short peptides that can inhibit viral infection and replication. They operate through various mechanisms, including blocking the binding of viruses to host cells, interfering with the viral replication process, and activating the host's immune response. Due to their broad-spectrum activity and low likelihood of resistance, antiviral peptides have garnered significant attention in the treatment of viral diseases such as influenza, HIV, and COVID-19. Research indicates that these peptides not only exhibit strong antiviral activity but also hold potential as a foundation for the development of new antiviral drugs.

Cell-penetrating Peptide

Cell-penetrating peptides are short peptides capable of effectively penetrating cell membranes. They enter cells through various mechanisms, including direct penetration, endocytosis, and interactions with the cell membrane. Due to their unique properties, CPPs show great potential in drug delivery, gene therapy, and vaccine development. Research indicates that these peptides can carry biomolecules, such as proteins and nucleic acids, into cells, thereby enhancing therapeutic efficacy and reducing side effects.

Polystyrene Surface Binding Peptide

Polystyrene surface binding peptides are short peptides that can specifically bind to the surface of polystyrene materials. These peptides interact with the chemical structure of polystyrene, enhancing its surface functionality and biocompatibility. Due to their strong binding capabilities, these peptides have significant potential applications in biosensors, drug delivery systems, and tissue engineering. Research has shown that polystyrene surface binding peptides can improve material performance and promote cell adhesion and proliferation.

Quorum Sensing Peptide

Quorum sensing peptides are short peptides used for intercellular communication in bacteria and other microorganisms. These peptides help microbes sense their population density by regulating gene expression, allowing them to coordinate behaviors such as biofilm formation, toxin release, and antibiotic production. The quorum sensing mechanism enables microorganisms to synchronize their collective actions under favorable environmental conditions, enhancing their survival and adaptability. These peptides play a significant role in microbial ecology and disease control.

Reference

Kawashima S, Pokarowski P, Pokarowska M, Kolinski A, Katayama T, Kanehisa M. AAindex: amino acid index database, progress report 2008. Nucleic Acids Res. 2008 Jan;36(Database issue):D202-5. doi: 10.1093/nar/gkm998. Epub 2007 Nov 12. PMID: 17998252; PMCID: PMC2238890.

Kyte J, Doolittle RF. A simple method for displaying the hydropathic character of a protein. J Mol Biol. 1982 May 5;157(1):105-32. doi: 10.1016/0022-2836(82)90515-0. PMID: 7108955.